Scientific Program - 16th International Workshop on Resistance to Thyroid Hormone and Thyroid Hormone Action

Scientific Program

Tuesday, Sept 1st

Wednesday, Sept 2nd

Thursday, Sept 3rd

Friday, Sept 4th

09:00 - 10:30

Session 1: NEURONAL ACTIONS

09:00 – 09:15 Robert Opitz (PI)

Epigenomic effects of TH action

09:00 – 09:15 Sergio Escamilla (PI: Federico Salas-Lucia)

Role of DIO3 and dependent T3 action in neuronal differentiation, maturation, and identity selection

09:30 – 09:45 Juliana Santos Romeo (PI: Ricardo Sousa)

Understanding How thyroid hormone signals via the TRs to Hypothalamic PVN Neurons

10:45 – 10:30 Discussion: Opitz, Salas-Lucia, Sousa

Understanding How thyroid hormone signals via the TRs to Hypothalamic PVN Neurons

10:30 – 11:00 Posters, coffee & tea

11:00 - 13:00 Session 2: INJURY AND REPAIR

(Moderator: Graham Williams)

11:00 – 11:15 Randy Stout (PI)

TH-related genes in astrocytes and neurons in the context of TBI, illustrating the model of intercellular gene regulations

11:15 – 11:30 Makoto Nakamura (PI: Huang Guo)

Thyroid hormone regulation of vascular regeneration

11:30 – 11:45 Caterina Miro (PI: Monica Dentice)

The role of thyroid hormone in muscle physiology

11:45 – 12:00 Sheue-Yann Cheng (PI)

Novel Functions of TRa1 in Cancer

12:00 – 13:00 Discussion: Stout, Guo, Dentice, Cheng

13:00 – 14:00 Lunch

14:00 – 14:45 PLENARY LECTURE

(Moderator: Robert Opitz to introduce)

Hans Clevers – Organoids

14:45 – 15:45 Session 3: TRANSPORTER in the BRAIN

(Moderator: Heike Heuer)

14:45 – 15:00 Aliza Avitan (PI: Gad Vatine)

MCT8 regulates functional and molecular maturation of human spinal motor neurons.

15:00 – 15:15 Andrea Alcaide Martin (PI: Steffen Mayerl)

Impact of thyroid hormone transporters Mct8/Oatp1c1 on hippocampal neurotransmission and seizure susceptibility

15:15 – 15:45 Discussion: Vatine, Mayerl

15:15 – 15:45 Posters, coffee & tea

16:15 - 18:15 Session 4: MECHANISM

(Moderator: Krishna Chatterjee))

16:15 – 16:30 Greg Brent (PI)

Desumoylated TRalpha protects against hepatic liver fat deposition in mice on a high fat diet

16:30 – 16:45 Susmita Dutta (PI Samuel Refetoff)

Transgenerational transmission of RSTH in humans is mediated through DIO3 methylation

16:45 – 17:00 Jasmin Schmidt (PI: Sebastian Hones and Duncan Bassett)

G-quadruplexes and their role in THRA splicing

17:00 – 17:15 Megan Ritter (PI)

Determining How TR CoRepressors Determine Chromatin Accessibility to Mediate Target Gene Regulation.

17:15 – 18:15 Discussion: Brent, Refetoff, Bassett, Ritter

19:00 Opening Reception

8:30 - 10:30 Session 7: DEIODINASES and SELENOPROTEINS

(Moderator: Arturo Hernandez)

8:30 – 8:45 Ulgu Arslan Van Bergen (PI: Edward Visser)

Molecular mechanisms underlying neurological phenotype in SBP2 deficiency.

8:45 – 9:00 Victor Vacarel (PI: Sylvie Remaud)

DIO2/neural stem cell

9:00 – 9:15 Jesus Moreno (PI: Alex Dumitrescu)

Cell specific characterization of low bone mass phenotype in SECISBP2 deficiency

9:15 – 9:30 Tommaso Porceli (PI: Domenico Salvatore)

Deiodinases in Thyroid Tumorigenesis

9:30 – 10:30 Discussion: Visser, Remaud, Dumitrescu, Salvatore

10:30 – 11:00 Posters, coffee & tea

11:00 - 13:00 Session 8: LIVER and METABOLISM

(Moderator: Becky Taub)

11:00 – 11:15 Alcantara Lopez (PI: Jens Mittag)

Liver Metabolism

11:15 – 11:30 Xinru Zhang (PI: Eveline Bruinstroop)

The role and regulation of Type 1 deiodinase by HNF4A in liver

11:30 – 11:45 Yingfu Chen ((PI: Eva Wirth)

Deiodinases in hepatic energy metabolism

11:45 – 12:00 Maria Ponte (PI: João Anselmo)

Liver-derived proteins CD5L, Ferritin and Ceruloplasmin in individuals with Resistance to Thyroid Hormone Beta and unaffected family members

12:00 – 13:00 Discussion: Mittag, Bruinstroop, Wirth, Anselmo

13:00 – 14:00 Lunch

14:00 – 15:30 Session 9: TH in DEVELOPMENT

(Moderator: Hans Clevers)

14:00 – 14:15 Yun-Bo Shi (PI)

Complementary and additive functions of TRα and TRβ in regulating larval cell death and adult stem cell development during Xenopus intestinal metamorphosis

14:15 – 14:30 Duncan Bassett (PI)

The role and regulation of Type 1 deiodinase by HNF4A in liver

11:30 – 11:45 Graham Williams (PI)

Developmental consequences of targeted disruption of TRα alternative splicing in vivo

11:45 – 12:00 Maria Ponte (PI: João Anselmo)

14:45 – 15:30 Discussion: Shi, Bassett, Williams

15:30 – 16:00 Posters, coffee & tea

16:00 - 17:00 Session 10: BEHAVIOUR

(Moderator: Jens Mittag)

16:00 – 16:15 Logan Douglas (PI: Arturo Hernandez)

Effects of type 3 deiodinase deficiency on reward systems and associated behaviors.

16:15 – 16:30 Soledad Bárez López (PI)

How thyroid hormones regulate oxytocin pathways and mood-related brain function

16:30 – 17:00 Discussion: Hernandez, Bárez López

17:00 – 17:45 PLENARY LECTURE

(Moderator: Leonidas Duntas)

Rebecca Taub – Resmetirom

19:00 Farewell Dinner

10:00 – 10:30 Posters, coffee & tea

10:30 - 12:30 Session 12: PHARMACOLOGY

(Moderator: Edward Visser)

10:30 – 10:45 Irene Campi (PI: Luca Persani)

Management with and without TRIAC of pediatric RTHbeta cases

10:45 – 11:00 Tom Scanlan (PI)

Mechanism of action of elunetirom (ABX-002), a brain-penetrating thyroid hormone agonist

11:00 – 11:15 Rajas Sane (PI: Joseph Koehrle)

High-throughput screening for selective inhibitors of five targets involved in local provision of thyroid hormones – DIOs 1,2,3, DEHAL1 & MCT8

11:15 – 11:30 Richárd Sinkó (PI: Petra Mohácsik)

Interferences of tissue thyroid hormone action and amiodarone treatment in vivo

11:30 – 12:30 Discussion: Persani, Scanlan, Koehrle, Mohácsik

12:30 – 13:30 Lunch vs boxes

14:00 Departure / ETA meeting